Familial Dysautonomia
Mode of Inheritance

How is familial dysautonomia inherited?

A person inherits one copy of the mutated gene from each of his parents. A carrier of FD has inherited only one copy of the mutated gene and is unaffected.

The gene for FD is found on chromosome 9. The gene for this disorder is called IKBKAP.

If two carriers have a child together, the child has a:
25% chance of having FD,
50% chance of being a carrier of FD,
25% chance of neither having nor carrying FD.
Unaffected siblings of those with FD have a 66% (2/3) chance of being carriers.

The general population has a 3% (1 in 30) chance of being a carrier of familial dysautonomia.

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